Research Study Expanded
In September of 2020, MGP expanded the study to include the IM administration of compound K9MGP given by an auto-injector simulator (AIS). This device rapidly injects the drug under pressure and is typically used to treat emergency situations. Examples would include administering naloxone to treat a narcotic overdose or giving epinephrine (EpiPen) to treat anaphylaxis. The device employed was designed by Oval Medical Technologies. The dose administered was 0.3 mg/Kg, and results compared to the data obtained with 0.3 mg/Kg given IM using the standard syringe with a 1 inch 23 gauge needle. The data obtained showed that the dose of K9MGP given by the AIS resulted in a plasma level of 50 ng/ml observed in 0.4-0.6 minutes following IM administration. This was significantly faster than observed with the same dose given using the standard manual injector. The conclusion of these results suggests that the administration of both 0.1 and 0.3 mg/Kg of K9MGP given IM via the AIS will result in immediate cessation of ongoing seizures in canines.